W1 – Core Analytes in a 6% Subsample

This page provides study documentation for Core Study W1.  For description of the specimen results, see Specimen Results Description (open to public). Data sets of the specimen results are included in the existing WHI datasets located on the WHI Data on this site (sign in and a completed Data Distribution Agreement are required; see details on the Data site).
 

Investigator Names and Contact Information

Core study approved by WHI Steering Committee

Introduction/Intent

Subsample and core analytes were specified in the original WHI RFP.

All CT participants provided a blood sample at baseline and year 1.  A 6% subsample of CT participants was randomly selected to provide additional blood samples at years 3, 6, and 9.  This 6% subsample was adjusted as recruitment progressed to include a six-fold oversampling of racial/ethnic minority women while retaining a 6% subsampling in each Clinical Center.  It selection also included a two-fold oversampling of HT (including HT and DM overlap) women (8.6%) as compared to DM-only women (4.3%). 

A total of 4,546 participants were selected to be in this 6% subsample.  The final numbers of the subsample women by racial/ethnic group and CT component are shown below.  Note that the totals by race/ethnicity take into account the approximate 10-14% participants who are in both the  HT and DM participants. 

 
 
Native American
Asian/Pacific Islander
Hispanic
African American
White
Other
HT
63
176
313
805
1,373
59
DM
75
197
407
695
1,296
55
Total
120
337
573
1200
2223
93
 
Each participant sample at each time point was tested for 20 ‘core analytes’.  These include:
   ·        Lipids: total cholesterol, HDL, HDL2, HDL3, LDL, triglyceride, apolipoprotein(a)
   ·        Metabolic:  glucose, insulin
     ·       Coagulation Factors:  Factor VII Ag (antigen), Factor VII C (clotting activity); fibrinogen
   ·        Micronutrients: alpha-carotene, alpha-tocopherol, beta-carotene, beta-cryptoxanthine, gamma-tocopherol, lycopene, lutein+zeaxanthin, retinol
 
Results/Findings
 
Assay methodologies can be found here.
 
For summary data by analyte, see the 2005 progress report for a summary of core analyte values by baseline and years 1, 3, 6, and differences between baseline and years 1, 3, and 6 for HT and DM participants.
 
See publications: 204, 210, 222, 240, 273, 345, 347, 350, 447, 448, 449, 520, 521, 524, 866. WHI publications by study lists published WHI papers that have been generated by ancillary studies. A complete list of WHI papers is available in the Bibliography section of this website.