WHI Study Pages

Note: This landing page is still being maintained, but may eventually be phased out. To search for and learn about our Ancillary Studies, please consider visiting the "Studies" page on the new WHI website.

The pages hosted on this site provide detailed information about each WHI study.  Detailed information on each page can include:

  • Study summary including introduction, results or publications, discussions, and references

  • Case/control/cohort sample selection and/or recruitment documents

  • Other relevant study documents

  • Data Dictionaries and data preparation documents

  • Study data, including raw and analytical datasets.

Note that biospecimens results are not included on these pages, and are instead included under Specimen Results under the Data tab.

In addition, Guidelines for AS Biospecimen Data Submission are available to ancillary study and BAA investigators on how to submit their study data to WHI. Beginning in 2013, study PIs are responsible for updating their specific study page with both the study information and study data. See the guidelines and Help Topics for further information.  

Access to the detailed information on each Study page is open to the public.  Access to study data has the same requirements as access to other WHI data, in which the investigator must sign a WHI Data Use Agreementand submit it to the WHI Helpdesk.

AS5Explanations for the development of fat distastePamela GreenDM
    Oral bone lossMarjorie JeffcoatOS
      450 Ppts @ Birmingham
      AS11Validation and exploration of sleep and mood predictorsDaniel KripkeOS
        AS13Prevalence and correlates of lumbar spinal stenosisMolly VogtCT
          AS14High density lipoprotein metabolismScott GoingOS
            AS15The relationship between osteopenia and periodontitisJean Wactawski-WendeOS
              AS17Domestic violence in older womenCharles MoutonOS
                AS24Cross-ethnic comparisons of skeletal health of postmenopausal women in San Diego countyDiane SchneiderOS
                  AS25Ankle-arm blood pressure index measurementKamal MasakiOS
                    AS31Eye care useRobert KleinsteinOS
                      AS33The association of HRT with abdominal and total body fat in postmenopausal womenCharlotte MayoOS
                        AS34Ethnic differences in hip bone geometry by DXA and QCTDorothy NelsonHT
                          AS36HRT and changes in mammographic densityBarbara HulkaHT
                          • breast C. (,0)
                          AS39The effects of HRT on the development and progression of dementia (WHIMS)Sally ShumakerHT
                            AS40Ethnic and age differences in use of  mammographySylvia SmollerOS
                              AS47Effect of diet intervention on motivation to make other health-related changesRobert LangerDM
                                AS48Prostate cancer survey of spouses of WHI screened womenSylvia SmollerGeneral population
                                  AS50Nutrition practice guidelines for maintaining low-fat dietary change in post menopausal womenBeth BurrowsDM
                                    AS56Behavioral and psychosocial predictors of dietary change in postmenopausal womenJoan PleussDM
                                      AS57Hispanic women's advocacy and retention strategiesCheryl RitenbaughOS
                                        AS60Fat intake in husbands of WHI dietary arm participantsJames ShikanyDM
                                          AS61Longitudinal assessment of memory functioning in the WHI clinical trialBeth OberHT
                                            AS62Prevention of age-related maculopathy in the WHI HRT CT: WHI-SEMary HaanHT
                                              AS63Development and evaluation of eating style indexPam HainesOS
                                                AS65Benign breast diseaseTom RohanDM
                                                  AS68Coronary artery calcification detected with ultrafast CT as an indication of CAD in OS participantsJudith HsiaOS
                                                    AS70The prevalence and prognostic importance of myocardial ischemia during daily life, and its relationship to migraine status: WHIDavid ShepsOS
                                                      AS73Psychosocial and cultural determinants of NIDDM in LatinasCheryl RitenbaughOS
                                                        AS74The effectiveness of individual versus group behavioral strategies to increase participants adherenceLois WodarskiDM
                                                          AS75Adherence to dietary modification in the WHIMilagros RosalDM
                                                            AS76Tailored messages to enhance adherence of older women to dietary programs for breast cancer controlRowan ChlebowskiDM
                                                              AS78Community strategy to retain women enrolled in researchMona FouadCT
                                                                AS82Extension of bone mineral density assessment in WHI Native American womenZhao ChenOS
                                                                  AS83Thrombotic, inflammatory and genetic markers for coronary heart disease in postmenopausal women: a WHI umbrella studyPaul RidkerOS
                                                                  • chd (650,0)
                                                                  • Controls (650)
                                                                  AS84Cognitive change in womenJulie DunnGeneral population
                                                                    AS86A pilot study to determine the sensitivity of form 39 to impaired executive controlfunction (ECF) as measured by the CLOX: an executive clock-drawing taskM.J. PolkHT
                                                                      AS90WHI sex hormone and genetic risk factors for hip fractureSteve CummingsOS
                                                                      • fracture - hip (400,400)
                                                                      • Controls (400)
                                                                      same as AS181
                                                                      AS93The epidemiology of venous diseaseMichael CriquiOS
                                                                        AS95Work organization, psychological distress, and health among minority older womenBeatriz RodriguezOS
                                                                          AS97Modeling serum markers for cost-effective ovarian cancer screeningGarnet AndersonOS
                                                                          • ovarian C. (280,280)
                                                                          • Controls (558)
                                                                          AS98Bone mineral density as a predictor for periodontitisJean Wactawski-WendeOS
                                                                            AS99Genetics of non-insulin dependent diabetes (GENNID)Rowan ChlebowskiGeneral population
                                                                              AS100Genetic, biochemical and behavioral determinants of obesityJennifer HaysOS
                                                                                AS102Quality of life improvements and willingness to pay:  an investigation of selective estrogen receptor modulatorsMona FouadOS
                                                                                  AS103Effects of hormone replacement therapy on cognitive aging:  Women's Health Initiative study of cognitive aging (WHISCA)Sally ShumakerHT
                                                                                    2266 ppts at 15 clinics
                                                                                    AS104Tamoxifen prevention:  Is it acceptable to women at risk?Joy MelnikowOS
                                                                                      AS105Carotenoids in age-related eye disease study (also see M1)Julie MaresOS
                                                                                      • eye (1000,2004)
                                                                                      • Controls (1000)
                                                                                      AS108Gene-environment effects and colorectal cancerHenry LinOS
                                                                                      • colorectal C. (50,50)
                                                                                      • Controls (150)
                                                                                      AS110Sex steroid hormones and risk of coronary heart disease:  a nested case control studyKathryn RexrodeOS
                                                                                      • chd (385,695)
                                                                                      • Controls (385)
                                                                                      79 matched cases-controls and 92 cases (but not controls) overlap with AS83.
                                                                                      AS111Glycemic index/glycemic load and blood lipids in the WHIJames ShikanyGeneral population
                                                                                        AS113Some aspects of mediterranean diet in relation to risk of chronic diseases among postmenopausal womenIman HakimOS
                                                                                          AS117Risk factors for dry eye syndrome in postmenopausal womenKelley NicholsOS
                                                                                            AS118Accuracy of food portion estimation among postmenopausal womenChristine CoyDM
                                                                                              AS121Hyperinsulinemia and ovarian cancerFrancesmary ModugnoOS
                                                                                              • ovarian C. (225,225)
                                                                                              • Controls (225)
                                                                                              originally a subset of AS97
                                                                                              AS122Feasibility study of computerized tailored dietary feedbackKaren GlanzDM
                                                                                                AS124Sociocultural influences on motivation for and maintenance of health-related dietary change among womenJoylin NamieDM
                                                                                                  AS126Stroke risk factors and molecular markers in postmenopausal womenSylvia Wassertheil-SmollerOS
                                                                                                  • stroke (972,972)
                                                                                                  • Controls (972)
                                                                                                  AS127CHD risk perception studyJanice BarnhartOS
                                                                                                    AS129Association of diabetes and insulin-like growth factor-I (IGF-I) with risks of colorectal, breast, and endometrial cancerHoward StricklerOS
                                                                                                    • endometrial C. (300,300)
                                                                                                    • colorectal C. (500,500)
                                                                                                    • breast C. (900,900)
                                                                                                    • Controls (900)
                                                                                                    same as AS152
                                                                                                    AS130Randomized controlled trial of fat reduction, calcium/Vitamin D supplementation, hormone replacement therapy, and risk of proliferative forms of benign breast diseaseTom RohanCT
                                                                                                    • benign breast disease (,3901)
                                                                                                    • Controls (0)
                                                                                                    AS132A prospective study of genetic and biochemical predictors of type 2 diabetes mellitusSimin LiuOS
                                                                                                    • type 2 diabetes (1800,1800)
                                                                                                    • Controls (2500)
                                                                                                    AS133Biochemical and genetic predictors of incident hypertension in white and black womenHoward SessoOS
                                                                                                    • hypertension (800,0)
                                                                                                    • Controls (800)
                                                                                                    AS134Serum estrogen hormone metabolites, hormone replacement therapy and the risk of breast cancerFrancesmary ModugnoOS
                                                                                                    • breast C. (200,200)
                                                                                                    • Controls (200)
                                                                                                    AS135Natural history of pelvic organ prolapse in WHI womenIngrid NygaardHT
                                                                                                      AS137Postmenopause CHD risk: platelet genes and hormone therapyPaul BrayOS
                                                                                                      • chd (1060,1060)
                                                                                                      • Controls (2120)
                                                                                                      AS139Follow-up of healthy breast cancer survivors in the WHI observational studyElectra PaskettOS
                                                                                                        AS140Air pollution and electrocardiographic abnormalities (environmental epidemiology of arrhythmogenesis in WHI)Eric WhitselCT
                                                                                                          AS141Periodontal disease and subclinical cardiovascular disease in post-menopausal womenJoan DornOS
                                                                                                            AS146A prospective study of pancreatic cancer pathogenesisCharles FuchsOS
                                                                                                            • pancreatic C. (104,104)
                                                                                                            • Controls (312)
                                                                                                            AS150Effect of airborne particulate matter and other air pollutants on the incidence of cardiovascular events in the Women's Health Initiative observational studyJoel KaufmanGeneral population
                                                                                                            • chd (,0)
                                                                                                            AS152Growth factor genes and female breast, colorectal, and endometrial cancersGloria HoOS
                                                                                                            • colorectal C. (500,500)
                                                                                                            • endometrial C. (300,300)
                                                                                                            • breast C. (900,900)
                                                                                                            • Controls (900)
                                                                                                            Same as AS129
                                                                                                            AS153Longitudinal changes in hip geometry and skeletal muscleZhao ChenOS
                                                                                                            • fracture - hip (,0)
                                                                                                            AS160An assessment of symptoms and symptom self-management for women abruptly stopping hormone replacement study pillsBarbara ValanisHT E+P
                                                                                                              AS161Bone mass response to termination of estrogen + progestinJane CauleyHT E+P
                                                                                                                AS163Hormone use following the WHI E+P trial termination: a pilot studyJennifer HaysHT E+P
                                                                                                                  AS165Subclinical thyroid dysfunction and risk of myocardial infarction and strokeCarol LorenzOS
                                                                                                                  • stroke (591,591)
                                                                                                                  • chd (800,800)
                                                                                                                  • Controls (3136)
                                                                                                                  AS167Sex hormones, risk factors, and risk of ER+ and ER- breast cancerSteve CummingsOS
                                                                                                                  • breast C. (311,0)
                                                                                                                  • Controls (592)
                                                                                                                  AS171Analysis of heart rate variability from ultra-short records:  the WHI studyYvonne MichaelCT
                                                                                                                    AS175Physical function determinants in minority womenJ. Skye NicholasOS
                                                                                                                      AS177Relative risk differences between FFQs and food recordsAmy SubarDM
                                                                                                                        AS178Mammographic density and invasive breast cancerEtta PisanoCT
                                                                                                                        • breast C. (,0)
                                                                                                                        AS179Frailty in WHI: drugs, inflammatory and genetic markersAndrea LaCroixOS
                                                                                                                        • frailty-disability (900,0)
                                                                                                                        • Controls (900)
                                                                                                                        AS181Estradiol, cytokines, and bone turnover:  effects on hip fractureJane CauleyOS
                                                                                                                        • fracture - hip (400,400)
                                                                                                                        • Controls (400)
                                                                                                                        same as AS90
                                                                                                                        AS183Effects of hormone therapy on subclinical neurological pathology: WHIMS-MRISally ShumakerHT E+P
                                                                                                                          1450 ppts at 14 WHIMS clinics
                                                                                                                          AS187Serum fatty acids and incidence of ischemic stroke in womenKa HeOS
                                                                                                                          • stroke (971,972)
                                                                                                                          • Controls (971)
                                                                                                                          shares cases and controls with AS 126
                                                                                                                          AS189Biochemical and anthropometric heterogeneity among morbid obese women in the Women's Health Initiative observational studyRachel MackeyOS
                                                                                                                          • chd (144,0)
                                                                                                                          • Controls (1172)
                                                                                                                          AS191Biomarkers and genetic factors related to sarcopenia in older women (includes AS199)Zhao ChenOS
                                                                                                                          • sarcopenia (2800,0)
                                                                                                                          2800 for DNA, subset of 1400 for EDTA
                                                                                                                          AS192Estrogen and progesterone-related genes and colorectal cancer riskShumin ZhangOS
                                                                                                                          • colorectal C. (644,0)
                                                                                                                          • Controls (1288)
                                                                                                                          Requests 10% blind duplicates (96 pairs)
                                                                                                                          AS195Candidate pathways in colorectal carcinogenesis: one-carbon metabolism and inflammationCornelia UlrichOS
                                                                                                                          • colorectal C. (988,0)
                                                                                                                          • Controls (988)
                                                                                                                          Same cases/controls as AS 206 where possible
                                                                                                                          AS196Heart failure evaluation in post-menopausal women: the Women's Health Initiative studyLiviu KleinHT
                                                                                                                            AS197Validity of self-reported diabetes mellitus in the Women's Health InitiativeKaren MargolisCT
                                                                                                                              AS199Genetic factors of muscle loss (added to AS191)Zhao ChenOS
                                                                                                                              • sarcopenia (800,0)
                                                                                                                              • Controls (2000)
                                                                                                                              Combined with AS191
                                                                                                                              AS206The effects of estrogen-alone hormone therapy on body compositionUlrike PetersOS
                                                                                                                              • colorectal C. (805,0)
                                                                                                                              • Controls (805)
                                                                                                                              Same cases/controls as AS195; controls include 100 Y3 samples
                                                                                                                              AS207IGF and multiple myelomaGraham ColditzGeneral population
                                                                                                                              • multiple myeloma (197,0)
                                                                                                                              • Controls (394)
                                                                                                                              AS208Pro and anti-inflammatory cytokines and colorectal cancerGloria HoOS
                                                                                                                              • colorectal C. (500,500)
                                                                                                                              • Controls (900)
                                                                                                                              same cases/controls as AS 129
                                                                                                                              AS214Prospective cohort collaborative in pancreatic cancer epidemiology and pathogenesis (AS146 extension)Charles FuchsOS
                                                                                                                              • pancreatic C. (209,0)
                                                                                                                              • Controls (418)
                                                                                                                              Assays done on those missing in AS146; Pilot: 40 AV3 samples from controls
                                                                                                                              AS216Decision-making about cancer screening among older womenCatherine MessinaGeneral population
                                                                                                                                1300 Ppts @ Stonybrook
                                                                                                                                AS217Validation of the self-report of rheumatoid arthritis and systemic lupus erythematosus: The Women's Health InitiativeBrian WalittCT
                                                                                                                                  AS218WHI nutrition and physical activity assessment study (NPAAS)Ross PrenticeOS
                                                                                                                                    450 Ppts @ 9 clinics
                                                                                                                                    450 Ppts @ 9 clinics
                                                                                                                                    AS219Diet and eye health in the WHI: end of trial study:  pilot studyJulie MaresDM
                                                                                                                                      AS220Neighborhoods, women, and coronary heart disease: a prospective studyCloe BirdGeneral population
                                                                                                                                        AS223Women's Health Initiative cancer survivor cohort: biological, psychosocial, and behavioral predictors of survival:  pilot studyElectra PaskettGeneral population
                                                                                                                                          AS224GWAS for nonsynonymous SNPs in colon cancerUlrike PetersGeneral population
                                                                                                                                          • colon C. (1309,2063)
                                                                                                                                          • Controls (1309)
                                                                                                                                          Stage 1:  GWAS 556 cases/69 controls, Caucasian only; Stage 2: GWAS 1309/1309 cases/controls; Stage 3:  7600 SNPs
                                                                                                                                          AS226Socioeconomic and environmental disparity of sleep disturbance Jiu-Chiuan ChenGeneral population
                                                                                                                                            AS233WHIMS (AS39) extensionSally ShumakerHT
                                                                                                                                              3070 Ppts @ 32 clinics
                                                                                                                                              AS235Pilot study to explore assoc between task performance on fMRI w/ cog functioning and vascular, genetic & inflam. risk factors in WHISCA ppt characterized by differing body weight & waist-hip ratiosDiana KerwinCT
                                                                                                                                                122 Ppts @ Milwaukie
                                                                                                                                                AS236Choline/betaine habitual intake and chronic disease endpointsAnna Maria Siega-RizGeneral population
                                                                                                                                                  AS238Biochemical predictors of type 2 DM in womenSimin LiuOS
                                                                                                                                                  • type 2 diabetes (700,699)
                                                                                                                                                  • Controls (1400)
                                                                                                                                                  Only minorities from AS132
                                                                                                                                                  AS242DNA repair, telomere length and cutaneous malignant melanoma riskJiali HanOS
                                                                                                                                                  • melanoma - skin (259,0)
                                                                                                                                                  • Controls (259)
                                                                                                                                                  Malignant melanoma
                                                                                                                                                  AS243Validation of direct measures of physical activity: an ancillary study to the Women's Health Initiative (WHI) Nutrition and Physical Activity Assessment Study (NPAAS; AS218)Barbara SternfeldOS
                                                                                                                                                    70 Ppts @ Oakland
                                                                                                                                                    AS244Women's Health Initiative memory study epidemiology of cognitive health (WHIMS-ECHO)Sally ShumakerHT
                                                                                                                                                      AS250Genetic contributions to cognitive decline in normal and pathological aging in older post-menopausal women and modification by hormone therapyIra DriscollHT
                                                                                                                                                      • Controls (7479)
                                                                                                                                                      Phase 1: 2,266 WHISCA; Phase 2: 719 WHIMS.  Phase 3 not yet funded for remaining 4,500 WHIMS
                                                                                                                                                      AS251Acute cardiovascular disease & air pollution in WHI-Phase IGreg WelleniusGeneral population
                                                                                                                                                        AS252Environmental determinants of cognitive aging in WHIMSJiu-Chiuan Chen


                                                                                                                                                        • HRT E+P in WHIMS (4532)
                                                                                                                                                        • HRT E-alone in WHIMS (2947)
                                                                                                                                                        • WHIMS-Y (2800)              
                                                                                                                                                        AS254Telomere and its biochemical and genetic regulators as predictors for clinical diabetes in womenSimin LiuOS
                                                                                                                                                        • type 2 diabetes (1800,0)
                                                                                                                                                        • Controls (2620)
                                                                                                                                                        AS257Nutritional and genetic risk factors for age-related macular degenerationJulie MaresOS
                                                                                                                                                        • eye (361,0)
                                                                                                                                                        • Controls (1426)
                                                                                                                                                        PI has a list of participants from AS105-CAREDS
                                                                                                                                                        AS262Women's Health Initiative memory study of younger women (WHIMS-Y)Sally ShumakerHT
                                                                                                                                                          All HT ppts aged 50-54 at randomization
                                                                                                                                                          AS263Gene-hormone therapy interaction and the risk of breast cancerJielin SunGeneral population
                                                                                                                                                          • breast C. - invasive (2690,0)
                                                                                                                                                          • Controls (1800)
                                                                                                                                                          583 E+P and 307 E-alone cases for GWAS; 1800 OS case/control pairs for sequencing
                                                                                                                                                          AS264Modification of PM-Mediated Arrhythmogenesis in Populations (MOPMAP)Eric WhitselGeneral population
                                                                                                                                                          • Controls (3094)
                                                                                                                                                          5 geographical locations; ppts with ECG readings
                                                                                                                                                          AS266Serum levels of EGFR-signaling-network activators/inhibitor and risk of lung cancerGloria HoGeneral population
                                                                                                                                                          • C. of lung (1384,0)
                                                                                                                                                          • Controls (1601)
                                                                                                                                                          1:2 matching for never smokers, 1:1 matching for former/current smokers; 321 CT control ppts; 500 cases from BA06
                                                                                                                                                          AS271Omega-3 and omega-6 fatty acids as a biomarker of hip fracture riskRebecca JacksonGeneral population
                                                                                                                                                          • fracture - hip (400,0)
                                                                                                                                                          • Controls (400)
                                                                                                                                                          half BMD, half non-BMD
                                                                                                                                                          AS272WHI Nutrition and Physical Activity Assessment Study (NPAAS) (Competitive Renewal)Ross PrenticeGeneral population
                                                                                                                                                            AS275Urinary levels of melatonin and risk of breast cancerSusan SturgeonOS
                                                                                                                                                            • breast C. - invasive (260,0)
                                                                                                                                                            • Controls (519)
                                                                                                                                                            AS282Evaluation of serum markers for use in multi-stage ovarian cancer screeningNicole UrbanGeneral population
                                                                                                                                                            • ovarian C. (183,463)
                                                                                                                                                            • Controls (732)
                                                                                                                                                            AS284Obesity-related pathways and risk of benign proliferative breast diseaseTom RohanCT
                                                                                                                                                            • benign breast disease (700,0)
                                                                                                                                                            • Controls (1400)
                                                                                                                                                            AS286OPACH: Objective physical activity and cardiovascular health in women aged 80 and olderAndrea LaCroixGeneral population
                                                                                                                                                              6500 E+P women, 2500 E - alone women, 1000 SHARe participants
                                                                                                                                                              AS287Metabolic Syndrome, Lifestyle Factors and Risk of Periodontitis in Older Women​Michael LaMonte


                                                                                                                                                              • completed comprehensive dental exam at baseline and 5 years (670)
                                                                                                                                                              AS289Pooling validation studies with recovery biomarkersVictor Kipnis


                                                                                                                                                              • NBS sub-study (544)
                                                                                                                                                              AS290Cadmium exposure and risk of breast cancer in the WHIPolly NewcombGeneral population
                                                                                                                                                              • breast C. - invasive (508,0)
                                                                                                                                                              • Controls (1000)
                                                                                                                                                              AS292Advanced glycation end products, the receptor, and colorectal cancer risk in WHILi JiaoOS
                                                                                                                                                              • colorectal C. (425,0)
                                                                                                                                                              • Controls (791)
                                                                                                                                                              From AS129
                                                                                                                                                              AS294Investigation of one-carbon metabolism pathway and lung cancer with the cohort consortiumPaul BrennanGeneral population
                                                                                                                                                              • C. of lung (238,242)
                                                                                                                                                              • Controls (238)
                                                                                                                                                              AS296Cohort consortium study of etiology of hepatocellular carcinoma in the United StatesKatherine McGlynnGeneral population
                                                                                                                                                              • C. of liver (121,0)
                                                                                                                                                              • Controls (242)
                                                                                                                                                              AS297Associations of estrogens, estrogen metabolites, and androgens with risks of endometrial and ovarian cancers in a prospective case-cohort studyBritton TrabertOS
                                                                                                                                                              • endometrial C. (430,0)
                                                                                                                                                              • ovarian C. (240,0)
                                                                                                                                                              • Controls (540)
                                                                                                                                                              AS301GWAS of Non-Hodgkins LymphomaSonja BerndtGeneral population
                                                                                                                                                              • Lymphoma, non hodgkins (1,580)
                                                                                                                                                              • Multiple myeloma (349)
                                                                                                                                                              • Hodgkin lymphoma (47)
                                                                                                                                                              • Controls (700)
                                                                                                                                                              AS303Saliva and serum inflammatory biomarkers in periodontitis: A study in older womenJean Wactawski-WendeGeneral population
                                                                                                                                                                AS304Vitamin D status and periodontal diseaseAmy MillenGeneral population
                                                                                                                                                                  AS308Heavy metals and renal cell cancer risk (Pilot study)Robin WilsonGeneral population ​​
                                                                                                                                                                  AS311Global DNA methylation measured in prospectively collected blood samples and risk of bladder cancer among post-menopausal womenParveen BhattiGeneral population
                                                                                                                                                                  • C. of bladder (530,0)
                                                                                                                                                                  • Controls (530)
                                                                                                                                                                  Specifically papillary transitional cell bladder cancer
                                                                                                                                                                  AS315Epigenetic Mechanisms of PM-Mediated CVD RiskEric WhitselCT
                                                                                                                                                                  • Controls (4167)
                                                                                                                                                                  4,167 ppts from 6% CT subsample
                                                                                                                                                                  AS316Validation of promising breast cancer early detection biomarkersChristopher LiOS
                                                                                                                                                                  • breast C. - invasive (322,0)
                                                                                                                                                                  • Controls (322)
                                                                                                                                                                  blood within 17 months of dx; exclude cases from BA05
                                                                                                                                                                  ​AS321Gentoxic Estrogen Ratio: A Novel Estrogen Biomarker and Breast Cancer Risk​​Kerryn Reding

                                                                                                                                                                  ​OS, DM

                                                                                                                                                                  • Breast C.- invasive (481)
                                                                                                                                                                  • Controls (481)
                                                                                                                                                                  AS325Racial/Ethnic Differences in 25(OH)D and PTH Levels and CVD among Women​Yiqing Song


                                                                                                                                                                  • White CVD cases (1,500)
                                                                                                                                                                  • White non-cases (1,500)
                                                                                                                                                                  • Black CVD cases (550)
                                                                                                                                                                  • Black non-cases (1,300)
                                                                                                                                                                  AS327Serum 25-hydroxyvitamin D and lung cancer risk in never-smoking, postmenopausal womenMarian NeuhouserGeneral population
                                                                                                                                                                  • C. of lung (300,0)
                                                                                                                                                                  • Controls (300)
                                                                                                                                                                  AS332Utility of the AVIIR score in predicting incident coronary heart disease in the WHIThemistocles (Tim) AssimesGeneral population
                                                                                                                                                                  • chd (700,0)
                                                                                                                                                                  • Controls (700)
                                                                                                                                                                  case cohort design  ~700 cases with incident CHD within 5 years of baseline/700 random controls
                                                                                                                                                                  AS337Lymphocyte subpopulations and clonal expansions in older women: epidemiologic factors and relationship to health and aging during the WHI 2010-2015 Extension
                                                                                                                                                                  Kerstin EdlefsenCT
                                                                                                                                                                    first 2,000 women (50% white, 50% African American) from the Home Visit
                                                                                                                                                                    AS340Evidence for Establishing Optimum Protein Intake in Older AdultsJeannette BeasleyGeneral population
                                                                                                                                                                      AS343Cardiovascular disease biomarkers and mediation of hormone therapy effectsRoss PrenticeHT
                                                                                                                                                                      • chd (20,20)
                                                                                                                                                                      • stroke (22,20)
                                                                                                                                                                      • Controls (42)
                                                                                                                                                                      Cases and controls are from the W57 participants in the 6% subsample
                                                                                                                                                                      AS346Serum, vitamin D, and risk of melanoma in WHI-OSJean TangOS
                                                                                                                                                                      • melanoma - skin (718,0)
                                                                                                                                                                      • Controls (718)
                                                                                                                                                                      Whites only
                                                                                                                                                                      AS349Exomic analysis of cardiovascular risk factors in minority women from WHI​Charles Kooperberg

                                                                                                                                                                      ​OS, CT

                                                                                                                                                                      • dbGaP-eligible (20,000)
                                                                                                                                                                        • ~12,151 African American
                                                                                                                                                                        • ~5,468 Hispanic
                                                                                                                                                                        • ~3,500 Asian
                                                                                                                                                                        • ~600 Native American
                                                                                                                                                                        • ~6,000 European American
                                                                                                                                                                      AS352(Pilot study) Trial of a cocoa supplement and multivitamin for CVD and cancer prevention among WHI participantsJoAnn MansonGeneral population
                                                                                                                                                                        AS355​Trial of a cocoa supplement and multivitamin for CVD and cancer prevention among WHI participants​JoAnn Manson

                                                                                                                                                                        ​OS, CT

                                                                                                                                                                        • High risk of CVD (12,000) 
                                                                                                                                                                        ​AS362Advanced Glycation End-products and Risk of Obesity-related Pancreatic Cancer

                                                                                                                                                                        ​OS, CT

                                                                                                                                                                        There is overlap between the two aims:

                                                                                                                                                                        • Serological Aim:  1,480 (494 pancreatic cancer cases + 986 controls)

                                                                                                                                                                        • Genetic Aim:  2,144 (715 pancreatic cancer cases + 1,429 controls)
                                                                                                                                                                        AS370WHI cancer survivor cohort (LILAC)Garnet AndersonGeneral population
                                                                                                                                                                          AS373Understanding older smokers' unique challenges in quitting:  prelude to a smoking cessation RCT in the WHI extension 2Hilary Tindle

                                                                                                                                                                          General population

                                                                                                                                                                          • OS smokers at year 6 or close-out (400; SE RC ppts only)
                                                                                                                                                                          • CT smokers at year 6 or close-out (400; SE RC ppts only)              
                                                                                                                                                                          AS374​Biomarkers of HPV infection and risk of two increasing cancers within the NCI cohort consortiumPaul Brennan
                                                                                                                                                                          Nicolas Schlecht

                                                                                                                                                                          ​OS, CT

                                                                                                                                                                          • Head/neck cancer (61)
                                                                                                                                                                          • Anal cancer (85)
                                                                                                                                                                          • Vaginal cancer (29)
                                                                                                                                                                          • Controls (350)
                                                                                                                                                                          AS376Estrogen therapy and incident end-stage renal disease in post-menopausal womenNora FranceschiniGeneral population
                                                                                                                                                                            AS377Health risks and benefits from calcium and vitamin D supplementations:  analysis of WHI dataRoss PrenticeGeneral population
                                                                                                                                                                              AS383Circulating vitamin D levels & risk of breast and colorectal cancer:  a pooled analysisStephanie Smith-WarnerCaD
                                                                                                                                                                              • breast C. - noninvasive (29,0)
                                                                                                                                                                              • colorectal C. (29,0)
                                                                                                                                                                              From W24 and W15
                                                                                                                                                                              AS384Methylation profiling of early stage lung tumors in short and long-term survivors (Pilot to AS370)Garnet AndersonGeneral population
                                                                                                                                                                                AS386Natural environment and cardiovascular incidence and mortality: The WHIGeoffrey DonovanGeneral population
                                                                                                                                                                                  AS389​A Pooled Investigation of Multiple Myeloma Risk in Relation to Circulating Adiponectin Levels
                                                                                                                                                                                  AS391Defining and timing of sudden arrhythmic death in WHICharles EatonGeneral population
                                                                                                                                                                                    AS397Assessment of fibromyalgia and polysomatic distress in the Women’s Health Initiative: Pilot study​Brian Wallit​OS, CT  (593)
                                                                                                                                                                                    AS398Enhanced dietary assessment to evaluate post-trial cancer outcomes in the WHI Dietary Modification Trial.Lesley TinkerDM
                                                                                                                                                                                    • breast C. (796,0)
                                                                                                                                                                                    • ovarian C. (70,0)
                                                                                                                                                                                    AS402​AS402 - Biomarkers and risk of ALS​Alberto Ascherio

                                                                                                                                                                                    ​OS, CT

                                                                                                                                                                                    • ALS as underlying cause of death (121)
                                                                                                                                                                                    • Controls (242)
                                                                                                                                                                                    AS403Systemic and breast-cancer specific autoimmunity in the WHIChristine ParksGeneral population
                                                                                                                                                                                      100 Systemic lupus cases 368 breast cancer cases
                                                                                                                                                                                      AS407A feasibility study to assess the accuracy of self-reported glaucoma outcomes and participant interest in participating in ancillary hlaucoma studies​Thasarat Vajaranant

                                                                                                                                                                                      ​CAREDS and WHISE participants in MWRC

                                                                                                                                                                                      • Self-reported glaucoma (200)
                                                                                                                                                                                      AS411Novel predictors of excess mortality in women with rheumatoid arthritisRachel MackeyGeneral population
                                                                                                                                                                                      • Controls (162)
                                                                                                                                                                                      162 BAA20 with anti-CCP+ RA  participants who died during follow-up
                                                                                                                                                                                      AS413Feasibility of sleep apnea assessment in WHI participants: Prelude to an ancillary study of sleep, cardiovascular disease and cognitive impairment​Katie Stone​WHIMS participants (56)
                                                                                                                                                                                      AS414​Social networks and health among women in the WHI: A new area of inquiry?​Crystal Wiley Cené

                                                                                                                                                                                      ​SE RC participants

                                                                                                                                                                                      • Non-Hispanic white (50)
                                                                                                                                                                                      • African American (50)
                                                                                                                                                                                      • Hispanic (50) 
                                                                                                                                                                                      AS415Assessing DNA methylation relationships in blood and tumor tissueKathy MaloneGeneral population
                                                                                                                                                                                      • breast C. - invasive (60,0)
                                                                                                                                                                                      60 participants from W47 BTTP with tumor specimen available
                                                                                                                                                                                      AS416Biomarkers of human age and longevityRobert ReisGeneral population
                                                                                                                                                                                      • Controls (300)
                                                                                                                                                                                      100 women with plasma from baseline and Long Life Study; 100 short-lived and 100 long-lived women
                                                                                                                                                                                      AS417Dietary metabolite profiling of nutrition and physical assessmentDan RafteryGeneral population
                                                                                                                                                                                      • Controls (50)
                                                                                                                                                                                      50 NPAAS-FS
                                                                                                                                                                                      AS422Measuring cardiovascular biomarkers in WHI Native AmericansCharles KooperbergGeneral population
                                                                                                                                                                                      • Controls (594)
                                                                                                                                                                                      PAGE Native Americans - 594 (same as pull M6-350)
                                                                                                                                                                                      AS423​Validating Multiple Stable Isotope Measures of Diet Within the NPAAS Feeding Study (AS272)​Diane M. O’Brien​NPAAS-FS (AS272) participants (153)
                                                                                                                                                                                      AS425A Pilot Study of Urinary Bisphenol-A in the Womens Health InitiativeJuhua LuoGeneral population
                                                                                                                                                                                        AS427(Pilot study II) Trial of a cocoa supplement and multivitamin for CVD and cancer prevention among WHI participantsJoAnn MansonGeneral population
                                                                                                                                                                                          AS438​Novel Hemorrhagic Stroke Risk factors in WHI: Pilot Study
                                                                                                                                                                                          AS439Nutrition and physical activity interest survey ​​Marian Neuhouser
                                                                                                                                                                                          AS455Helicobacter pylori protein-specific antibodies and colorectal cancer risk​Meira Epplein


                                                                                                                                                                                          • Colorectal cancer (807)
                                                                                                                                                                                          • Controls (807)
                                                                                                                                                                                          AS458​Phthalate Metabolite and Breast Cancer Risk in the Women’s Health Initiative​Katherine Reeves


                                                                                                                                                                                          • Invasive breast cancer diagnosed after AV3 (500)
                                                                                                                                                                                          • Controls (1000)
                                                                                                                                                                                          AS461Epigenetics, dietary intake and ovarian cancer risk​Jeanine Genkinger

                                                                                                                                                                                          ​OS, CT

                                                                                                                                                                                          • Epithelial ovarian cancer (610)
                                                                                                                                                                                          • Controls (610)
                                                                                                                                                                                          AS464Classification of participants in the WHI by rural-urban residence​Michael Simon​General population
                                                                                                                                                                                          AS471​Macular pigment in aging and age-related eye disease

                                                                                                                                                                                          ​Julie Mares

                                                                                                                                                                                          Kristin Meyers


                                                                                                                                                                                          • CAREDS (AS105) survivors (1254)
                                                                                                                                                                                          AS476APOL1, sickle cell trait and chronic kidney disease in African Americans​Nora Franceschini​CT, OS, BMD
                                                                                                                                                                                          AS482​Serologic inflammatory markers and esophageal adenocarcinoma risk​Michael Cook

                                                                                                                                                                                          ​CT, OS

                                                                                                                                                                                          • Esophageal adenocarcinoma (51)
                                                                                                                                                                                          • Controls (51)
                                                                                                                                                                                          AS498Nutrition and Physical Activity Assessment Study (competitive renewal)

                                                                                                                                                                                          ​Marian Neuhouser

                                                                                                                                                                                          Johanna Lampe

                                                                                                                                                                                          ​CT, OS

                                                                                                                                                                                          • BMD participants with history of invasive breast, ovarian, endometrial, colorectal cancer (708)
                                                                                                                                                                                          • Controls (708)
                                                                                                                                                                                          • NPAAS (AS218) participants (450)
                                                                                                                                                                                          AS504A pilot study of a novel qPCR-based measure of relative Telomere Length in the Women’s Health Initiative​Tim Assimes

                                                                                                                                                                                          ​CT, OS

                                                                                                                                                                                          • White BA25 (non-cases) with available buffy coat and baseline 5' DNA (70)
                                                                                                                                                                                          • White AS254 participants with available buffy coat and baseline 5' DNA (25)
                                                                                                                                                                                          • Black BA25/AS254 overlap participants with available basline 5' DNA (25)
                                                                                                                                                                                          AS505Validation of colorectal cancer early detection markers​Paul Lampe


                                                                                                                                                                                          • Colorectal cancer (288)
                                                                                                                                                                                          • Controls (576)
                                                                                                                                                                                          AS508​​Prevalence and penetrance of breast cancer-associated mutations identified by multiple-gene sequencing​Allison Kurian


                                                                                                                                                                                          • Invasive breast cancer (2,500)
                                                                                                                                                                                          • Controls (2,500)
                                                                                                                                                                                          AS509Biomarkers of lung cancer risk​Mattias Johansson

                                                                                                                                                                                          ​CT control arms, OS

                                                                                                                                                                                          • 1321 participants with 1335 bio-specimens (445  lung cancer cases/ 890 sub-cohort members)
                                                                                                                                                                                          AS516APOL1, sickle cell trait and chronic kidney disease in aging women
                                                                                                                                                                                          ​Nora Franceschini

                                                                                                                                                                                          ​CT, OS

                                                                                                                                                                                          • African Americans not in PAGE 2 (AS349) (6304)
                                                                                                                                                                                          AS518​AS518 - A pilot RNA-seq study among Long Life Study participants of the WHI ​Tim Assimes

                                                                                                                                                                                          ​Long Life Study (LLS)

                                                                                                                                                                                          • African American LLS participants with no history of CVD, no incident CHD, and who have global DNA methylation (BAA23) and telemore (BAA25) (100)
                                                                                                                                                                                          AS523Feasibility study to evaluate haptoglobin phenotype and risk of coronary heart disease and stroke among diabetic women​​Richard Donahue

                                                                                                                                                                                          ​OS (400)

                                                                                                                                                                                          • 100 diabetic w/ Hx of CHD/revascularization
                                                                                                                                                                                          • 100 diabetic w/ Hx of stroke
                                                                                                                                                                                          • 100 diabetic w/ no Hx of stroke or CHD
                                                                                                                                                                                          • 100 non-diabetic w/ no Hx of stroke or CHD
                                                                                                                                                                                          AS525​Assessing sodium and potassium in 24-h and spot urines: feasibility of calibrating self-reported diet for use in WHI CVD association studies​Lesley Tinker

                                                                                                                                                                                          ​NPAAS-FS (AS272)

                                                                                                                                                                                          • NPAAS-FS participants (153)
                                                                                                                                                                                          AS534​Longitudinal study of DNA methylation as a mediator between age and cardiovascular risk​Karen Conneely

                                                                                                                                                                                          ​Long Life Study (LLS)

                                                                                                                                                                                          • AS315 participants with prior methylation analysis at two time points, and LLS DNA available for methylation analysis (43)
                                                                                                                                                                                          AS536​Targeted serum metabolites profiling in early detection of pancreatic cancer​Li Jiao

                                                                                                                                                                                          ​OS, non-active DM arm

                                                                                                                                                                                          • Pancreatic cancer (48)
                                                                                                                                                                                          • Controls (48)
                                                                                                                                                                                          AS537A novel endogenous SERM and cholesterol metabolite, 27-hydroxcholesterol, and fracture risk in postmenopausal women​Jennifer S. Lee

                                                                                                                                                                                          ​BAA07/W9 participants

                                                                                                                                                                                          • Hip fracture (242)
                                                                                                                                                                                          • Vertebral fracture (200)
                                                                                                                                                                                          • Controls (430) 
                                                                                                                                                                                          AS538​Genomic Analysis of Breast Cancer Genes in the WHI: Creation of a Public Genomics Resource​Mary-Claire King

                                                                                                                                                                                          ​CT, OS

                                                                                                                                                                                          • Participants in follow-up and cancer-free until at least age 65 (30,000)
                                                                                                                                                                                          AS543Exploring WBC BRCA1 methylation as a risk factor for incidental cases of high grade serous ovarian cancer and triple-negative breast cancer in WHI​Per E. Lonning

                                                                                                                                                                                          ​CT, OS

                                                                                                                                                                                          • Triple-negative breast cancer (668)
                                                                                                                                                                                          • Ovarian cancer (549)
                                                                                                                                                                                          • Controls (3928) 
                                                                                                                                                                                          AS545​Prospective identification of pre-leukemic clones in the peripheral blood of women with acute myeloid leukemia prior to the onset of overt disease​Pinkal Desai

                                                                                                                                                                                          ​CT, OS

                                                                                                                                                                                          • AML (213)
                                                                                                                                                                                          • Therapy related AML (13)
                                                                                                                                                                                          • Controls (210)
                                                                                                                                                                                          AS560​Serum and urine metabolite profiles of diet measured by weighed food​Steven C. Moore 
                                                                                                                                                                                          Mary C. Playdon

                                                                                                                                                                                          ​NPAAS Feeding Study (AS272)

                                                                                                                                                                                          • Participants (153)
                                                                                                                                                                                          AS562Sex steroid hormones in women and development of primary liver cancer​Katherine McGlynn


                                                                                                                                                                                          • Liver cancer (26)
                                                                                                                                                                                          • Controls (78)


                                                                                                                                                                                          • Liver cancer (90)
                                                                                                                                                                                          • Controls (165)
                                                                                                                                                                                          AS564Trans-Omics for Precision Medicine (TOPMed)​Charles Kooperberg

                                                                                                                                                                                          ​CT, OS

                                                                                                                                                                                          • Ischemic stroke (4000)
                                                                                                                                                                                          • VTE (1100)
                                                                                                                                                                                          • Hemorrhagic stroke (900)
                                                                                                                                                                                          • Controls (5100)
                                                                                                                                                                                          AS575Arsenic metabolic efficiency and risk of diabetes and cardiovascular disease​Krystal Pollitt

                                                                                                                                                                                          CT, OS

                                                                                                                                                                                          • AS466 participants
                                                                                                                                                                                            • Diabetes (400)
                                                                                                                                                                                            • Stroke (400)
                                                                                                                                                                                            • CHD (400)
                                                                                                                                                                                            • Controls (800)
                                                                                                                                                                                          • Additional cases
                                                                                                                                                                                            • Stroke (160)
                                                                                                                                                                                            • CHD (320)
                                                                                                                                                                                          AS584Epigenetic Age as a Marker of Reproductive Age and Modifier of Invasive Breast Cancer Risk among Postmenopausal Women
                                                                                                                                                                                          ​Alexandra Binder

                                                                                                                                                                                          ​BA23, AS311, AS315

                                                                                                                                                                                          • Existing genome-wide DNA methylation data (5,406)
                                                                                                                                                                                          ​Asprosin, body weight, and risk of type 2 diabetes in U.S. men and women 
                                                                                                                                                                                          ​Simin Liu
                                                                                                                                                                                          ​CT, OS
                                                                                                                                                                                          • 8362 participants (4,181 incident diabetes; 4,181 controls) for whom imputed GWAS data (SHARe / GARNET) or exome sequencing data or whole genome sequencing data are available.

                                                                                                                                                                                          AS591Genomic Characterization of Lung Cancer in Female Never-Smokers​Alice Berger


                                                                                                                                                                                          • lung cancer cases with adenocarcinoma histology (150)
                                                                                                                                                                                            • never-smokers (130)
                                                                                                                                                                                            • "heavy" smokers (20)
                                                                                                                                                                                          AS593 The Women’s Health Initiative (WHI) Industry and Occupation Coding​Yvonne Michael


                                                                                                                                                                                          • Participants responding to occupational history questionnaire at baseline (91,627)
                                                                                                                                                                                          AS603PREcision Disease preventIon via somatiC muTagenesis enumeratION (PREDICTION)​Jason Bielas


                                                                                                                                                                                          • Cancer cases (675)
                                                                                                                                                                                          • Controls (450) 
                                                                                                                                                                                          AS608Metabolomics, bacterial translocation and risk of liver cancer​Katherine McGlynn

                                                                                                                                                                                          ​CT, OS

                                                                                                                                                                                          • Participants from AS296 (240)
                                                                                                                                                                                            • Liver cancer (120)
                                                                                                                                                                                            • Controls (120)
                                                                                                                                                                                          • New cases (137) and controls (137)
                                                                                                                                                                                          AS611Effect of clonal hematopoiesis of indeterminate potential and calcium and Vitamin D supplementation on risk of hematological malignancies​Pinkal Desai

                                                                                                                                                                                          ​CT, OS

                                                                                                                                                                                          • Aim 1
                                                                                                                                                                                            • DLBCL (200)
                                                                                                                                                                                            • CLL (200)
                                                                                                                                                                                            • Controls (400)
                                                                                                                                                                                          • Aim 2
                                                                                                                                                                                            • Hematologic malignancies (333)
                                                                                                                                                                                            • Controls (333) 
                                                                                                                                                                                          AS615Investigating the Biology of Cognitive Resilience in WHIMS “APOE 4 Escapees”​Susan Resnick

                                                                                                                                                                                          ​WHIMS participants

                                                                                                                                                                                          • Cognitively impaired (900) 
                                                                                                                                                                                          • Controls (725)
                                                                                                                                                                                          AS620PanScan Genome-Wide Association Study for Pancreatic Cancer
                                                                                                                                                                                          ​Laufey Amundadottir/
                                                                                                                                                                                          Rachael Stolzenberg-Solomon

                                                                                                                                                                                          ​CT, OS

                                                                                                                                                                                          • Pancreatic cancer cases (600)
                                                                                                                                                                                          • Controls (600)
                                                                                                                                                                                          ​Biomarkers of oxidative stress, inflammation, and cardiac damage as markers of radiation-induced cardiovascular outcomes in breast cancer 
                                                                                                                                                                                          ​Alexi Vasbinder 
                                                                                                                                                                                          • Cardiotoxicity among breast cancer (~55)
                                                                                                                                                                                          • Controls (165)
                                                                                                                                                                                          Sleep, Metabolomics and Cardiovascular Health in Older Men and Women
                                                                                                                                                                                          ​Katie Stone
                                                                                                                                                                                          • Aim 1
                                                                                                                                                                                            • All ppts with accelerometry data.
                                                                                                                                                                                          • Aim 2
                                                                                                                                                                                            • CVD cases (375)
                                                                                                                                                                                            • Controls (750)
                                                                                                                                                                                          AS628Clonal Hematopoiesis of Indeterminate Potential (CHIP)​Alex Reiner/
                                                                                                                                                                                          Eric Whitsel
                                                                                                                                                                                          LLS participants (7800)
                                                                                                                                                                                          Rest-activity rhythms, dementia and Alzheimer's disease in older men and women: the role of metabolism and inflammation
                                                                                                                                                                                          ​Qian Xiao
                                                                                                                                                                                          ​LLS-OPACH, WHIMS
                                                                                                                                                                                          • 175 cognitive decline from LLS-OPACH + 425 controls (controls may be shared with AS624); Pilot: 75 cases with Alzheimer’s disease and related dementias [ADRD] and 75 controls who participated in WHIMS and LLS-OPACH
                                                                                                                                                                                          AS630Autoantibodies for Small Cell Lung Cancer Early Detection​Paul Lampe

                                                                                                                                                                                          ​CT, OS

                                                                                                                                                                                          • Small-cell lung cancer (80)
                                                                                                                                                                                          • Controls (160)
                                                                                                                                                                                          AS637​Investigating the Biology of Cognitive Resilience in WHIMS “APOE ε4 Escapees” using Blood Exosomes​Dimitrios Kapogiannis/
                                                                                                                                                                                          Susan Resnick
                                                                                                                                                                                          Role of FSH in postmenopausal obesity and breast cancer
                                                                                                                                                                                          ​Jennifer Bea
                                                                                                                                                                                          ​BMD/AS15, AS98, AS382
                                                                                                                                                                                          • From BMD/HT: 1,400 ( 95 cases + 1,305 controls)
                                                                                                                                                                                          • From BMD/non-HT: 1,210 ( 605 cases + 605 controls)
                                                                                                                                                                                          • From OsteoPerio Study: 685 (85 cases + 600 controls)

                                                                                                                                                                                          AS654Blood Metabolomic Profile of Glioma Risk: A Collaborative Multi-Cohort Project
                                                                                                                                                                                          ​Demetrius Albanes

                                                                                                                                                                                          ​CT, OS

                                                                                                                                                                                          • Malignant glioma (250)
                                                                                                                                                                                          • Controls (250)
                                                                                                                                                                                          ​Women’s Health Initiative Study of Clonal Hematopoiesis of Indeterminate Potential and the Risk of Cognitive Decline and Impairment in Older Women
                                                                                                                                                                                          ​Kathleen Hayden
                                                                                                                                                                                          ​WHIMS and AS628 participants (4,500)
                                                                                                                                                                                          ​A Multi-omics Resource for Sickle Cell Trait in African Americans from the Women’s Health Initiative
                                                                                                                                                                                          ​Alex Reiner/
                                                                                                                                                                                          Charles Kooperberg
                                                                                                                                                                                          ​CT, OS

                                                                                                                                                                                          3,000 African Americans:
                                                                                                                                                                                          • Aim 1 (baseline samples requested): 2,000 (1,000 African American sickle cell trait [SCT] cases + 1,000 African Americans without SCT)
                                                                                                                                                                                          • Aim 2 (baseline + LLS samples requested): 1,000 LLS African Americans without multi-omics through TOPMed (AS576)
                                                                                                                                                                                          • Aim 3 (baseline samples requested, participants overlap with aims 1 and 2): 800 LLS African Americans without WGS through TOPMed or CCDG (AS564)
                                                                                                                                                                                          DNA methylation as a novel epigenetic biomarker that regulates metabolic and inflammatory cytokines in the development of obesity attributable cancers
                                                                                                                                                                                          ​Su Yon Jung
                                                                                                                                                                                          ​CT, OS
                                                                                                                                                                                          • Breast cancer (500)
                                                                                                                                                                                          • Controls (500)
                                                                                                                                                                                          NSAID use and tumor inflammatory biomarkers in relation to ovarian cancer risk and survival
                                                                                                                                                                                          ​Britton Trabert et al.
                                                                                                                                                                                          • Invasive epithelial ovarian cancer (201)
                                                                                                                                                                                          Determinants of the racial/ethnic disparity in MGUS risk: An epidemiologic study in 4 cohorts
                                                                                                                                                                                          ​Pinkal Desai/
                                                                                                                                                                                          Wendy Cozen
                                                                                                                                                                                          • MGUS (877)
                                                                                                                                                                                            • Multiple myeloma (729)
                                                                                                                                                                                          • Controls (877)
                                                                                                                                                                                          Helicobacter Infection and Liver Cancer Risk among African Americans and Whites in the United States
                                                                                                                                                                                          ​Xuehong Zhang
                                                                                                                                                                                          ​CT, OS
                                                                                                                                                                                          • Liver cancer (325)
                                                                                                                                                                                          • Controls (750)
                                                                                                                                                                                          Epigenetic Aging Biomarkers of MCI, ADRD, and Brain Aging in the Women’s Health Initiative Memory Study
                                                                                                                                                                                          ​Aladdin Shadyab

                                                                                                                                                                                          ​WHIMS, LLS
                                                                                                                                                                                          • Mild cognitive impairment (1,336)
                                                                                                                                                                                          • Controls (7,504)
                                                                                                                                                                                          ​Interdisciplinary Epidemiologic Consortium to Investigate T-cell Response in Colorectal Cancer
                                                                                                                                                                                          ​Ulrike Peters/ Amanda Phipps/
                                                                                                                                                                                          Shuji Ogino
                                                                                                                                                                                          • ~450 CRC cases (All available cases with tumor tissue); only data is being requested for matched controls (1:4 ratio)
                                                                                                                                                                                          Air pollution adductomics and liver cancer risk
                                                                                                                                                                                          Trang VoPham​​AS296 participants
                                                                                                                                                                                          • Hepatocellular carcinoma (18)
                                                                                                                                                                                          • Controls (72)
                                                                                                                                                                                          Association of sex steroid hormones and biliary tract cancers in men and women
                                                                                                                                                                                          ​Jill Koshiol

                                                                                                                                                                                          ​CT, OS
                                                                                                                                                                                          • Aim 1
                                                                                                                                                                                            • Gallbladder cancer (41)
                                                                                                                                                                                            • Controls (82)
                                                                                                                                                                                          • Aim 2
                                                                                                                                                                                            • Extrahepatic bile duct cancer (16)
                                                                                                                                                                                            • Controls (32)

                                                                                                                                                                                          Pilot study of sensitive and specific clinical biomarkers of B vitamin deficiency and relationship to AMD
                                                                                                                                                                                          ​Julie Mares
                                                                                                                                                                                          Paul Jacques
                                                                                                                                                                                          ​OS, CAREDS Study
                                                                                                                                                                                          • Age-related macular degeneration (AMD, 100)
                                                                                                                                                                                          • Controls (100)

                                                                                                                                                                                          Feasibility of RNA sequencing using archival tumor specimens collected in WHI LILAC
                                                                                                                                                                                          ​Aditi Hazra
                                                                                                                                                                                          • 8-12 breast tumor blocks and unstained slides
                                                                                                                                                                                          BA1Ancestry association analyses of WHI traitsMichael SeldinGeneral population
                                                                                                                                                                                          • fracture - hip (950,950)
                                                                                                                                                                                          • Controls (22852)
                                                                                                                                                                                          Hip fractures in Whites; Controls = 950 hip fx controls, 400 low/400 high BMD in Blacks; all Blacks 14,618; all Hispanics 6,484
                                                                                                                                                                                          BA2High-dimensional genotype in relation to breast cancer and WHI clinical trial interventions​Ross Prentice​OS
                                                                                                                                                                                          • breast C. (2242,0)
                                                                                                                                                                                          • Controls (2242)
                                                                                                                                                                                          BA3Genome-wide association study to identify genetic components of hip fracture​Rebecca Jackson​​General population
                                                                                                                                                                                          • fracture - hip (2250,0)
                                                                                                                                                                                          • Controls (2250)
                                                                                                                                                                                          Stage I:  750 non-minority os cases/controls, Stage II:  1108 (350 OS+758 CT) cases/controls
                                                                                                                                                                                          BA4​Proteomics and the health effects of postmenopausal hormone therapy​Ross PrenticeOS
                                                                                                                                                                                          • breast C. (800,800)
                                                                                                                                                                                          • stroke (800,800)
                                                                                                                                                                                          • chd (800,800)
                                                                                                                                                                                          • Controls (2400)
                                                                                                                                                                                          Exclude 490 breast cancer cases from BA05-Li​
                                                                                                                                                                                          BA5Identification and validation of circulating biomarkers for the early detection of breast cancer in pre-clinical specimens​​Rongling Li​OS
                                                                                                                                                                                          • breast C. (930,0)
                                                                                                                                                                                          • Controls (930)
                                                                                                                                                                                          cases 6-19 months after baseline or Y3 blood draw
                                                                                                                                                                                          BA6Interaction effects of genes in the inflammatory pathway and dietary, supplement, and medication ​Jianfeng Xu​OS
                                                                                                                                                                                          • colorectal C. (600,0)
                                                                                                                                                                                          • C. of lung (564,0)
                                                                                                                                                                                          • breast C. (719,0)
                                                                                                                                                                                          • Controls (2120)
                                                                                                                                                                                          500 each in Whites, up to 500 in Blacks​
                                                                                                                                                                                          BA7Endogenous estradiol and the effects of estrogen therapy on major outcomes of WHI​​Steve Cummings​HT
                                                                                                                                                                                          • vte (422,0)
                                                                                                                                                                                          • stroke (534,0)
                                                                                                                                                                                          • fracture - not hip or spine (830,0)
                                                                                                                                                                                          • chd (753,0)
                                                                                                                                                                                          • fracture - spine only (204,0)
                                                                                                                                                                                          • Controls (873)
                                                                                                                                                                                          Prob Dement/Mild Cog Impair (310);  Cohort (563 = original 351+212 added June 2010)
                                                                                                                                                                                          BA8Predictive value of nutrient biomarkers for CHD death​​Alice Lichtenstein​OS
                                                                                                                                                                                          • chd (1224,0)
                                                                                                                                                                                          • Controls (1224)
                                                                                                                                                                                          add 2% cases/controls, include all CHD deaths
                                                                                                                                                                                          BA9​Biochemical antecedents of fracture in minority women​Jane Cauley​OS
                                                                                                                                                                                          • fracture (general) (1132,0)
                                                                                                                                                                                          • Controls (1132)
                                                                                                                                                                                          Exclude spine fx
                                                                                                                                                                                          BA10Adipokines and risk of obesity-related diseaseGloria HoOS
                                                                                                                                                                                          • breast C. (900,900)
                                                                                                                                                                                          • stroke (970,972)
                                                                                                                                                                                          • colorectal C. (500,500)
                                                                                                                                                                                          • endometrial C. (300,300)
                                                                                                                                                                                          • Controls (1870)
                                                                                                                                                                                          Same as AS126-Stroke and AS129-Ins-Glu
                                                                                                                                                                                          BA11Physical activity, obesity, inflammation and CHD in a multi-ethnic cohort of womenI-Minn LeeOS
                                                                                                                                                                                          • chd (601,0)
                                                                                                                                                                                          • Controls (1332)
                                                                                                                                                                                          Baseline+Y3:all Black, Hispanic, Asian, White up to 600 in cases; 300 of each ethnicity for controls
                                                                                                                                                                                          BA12Hormone therapy, estrogen metabolism and risk of breast cancer or hip fracture in the WHI hormone trialLew KullerHT
                                                                                                                                                                                          • fracture - hip (370,0)
                                                                                                                                                                                          • breast C. (900,0)
                                                                                                                                                                                          • Controls (1800)
                                                                                                                                                                                          Breast Cancer controls from W10-Breast Cancer core study
                                                                                                                                                                                          BA13Markers of B-cell stimulation as potential predictors of Non-Hodgkins lymphomaAnneclaire DeRoosOS
                                                                                                                                                                                          • lymphoma, non hodgkins (487,0)
                                                                                                                                                                                          • Controls (487)
                                                                                                                                                                                          BA14Inflammation and thrombosis gene pathways and cardiovascular diseaseAlexander ReinerGeneral population
                                                                                                                                                                                          • chd (3594,3594)
                                                                                                                                                                                          • stroke (2887,2887)
                                                                                                                                                                                          • vte (632,632)
                                                                                                                                                                                          • Controls (4361)
                                                                                                                                                                                          HT with OS to fill out controls
                                                                                                                                                                                          BA15Discovery and confirmation of cancer specific serum protein markers for ovarian cancer early detectionMartin McIntoshOS
                                                                                                                                                                                          • ovarian C. (225,0)
                                                                                                                                                                                          • Controls (225)
                                                                                                                                                                                          Dx within 36 mo of blood draw
                                                                                                                                                                                          BA16Identifying biomarkers for pancreatic cancerSunil HingoraniOS
                                                                                                                                                                                          • pancreatic C. (280,0)
                                                                                                                                                                                          • Controls (280)
                                                                                                                                                                                          BA17Proteomics based discovery of blood based biomarkers and risk factors for lung cancer among women smokers and never smokersSam HanashOS
                                                                                                                                                                                          • C. of lung (320,0)
                                                                                                                                                                                          • Controls (320)
                                                                                                                                                                                          30 pools of 10; 30 pools of 16
                                                                                                                                                                                          BA18Followup studies of genetically determined risk factorsRebecca JacksonGeneral population
                                                                                                                                                                                          • fracture - hip (400,0)
                                                                                                                                                                                          • Controls (7900)
                                                                                                                                                                                          2000 highest BMD + 2000 lowest BMD among non-Hispanic, non-Black for SNPs, subset of 400 for biomarkers; Mod for Stage #: 1500; Mod for Exome chip: 2000 (in addtion to 4000 previously included)
                                                                                                                                                                                          BA19Omega-3 fatty acid biomarkers and cognitive decline in WHIMSWilliam S. HarrisHT
                                                                                                                                                                                          • Controls (7371)
                                                                                                                                                                                          WHIMs ppts (1382 MRI, 1215 WHISCA, 4774 other)
                                                                                                                                                                                          BA20Evaluation of specific markers of rheumatoid arthritis, Inflammation, thrombogenesis and risk of cardiovascular disease and total mortalityLarry W. MorelandGeneral population
                                                                                                                                                                                          • Controls (9988)
                                                                                                                                                                                          9,988 self-reported RA
                                                                                                                                                                                          BA21Understanding the role of sex hormones in colorectal cancerMarc GunterCT
                                                                                                                                                                                          • colorectal C. (400,0)
                                                                                                                                                                                          • Controls (800)
                                                                                                                                                                                          excluding those in active HT arms
                                                                                                                                                                                          BA22Predictive modeling for CVD in a multiethnic cohort in womenNancy CookOS
                                                                                                                                                                                          • death - other cause (289,0)
                                                                                                                                                                                          • chd (933,0)
                                                                                                                                                                                          • stroke (812,0)
                                                                                                                                                                                          • Controls (2000)
                                                                                                                                                                                          includes all CHD and strokes from 3 minority groups
                                                                                                                                                                                          BA23Integrative genomics for risk of CHD and related phenotypes in the WHIPhil TsaoGeneral population
                                                                                                                                                                                          • chd (1070,0)
                                                                                                                                                                                          • Controls (1070)
                                                                                                                                                                                          Whites in HT GWAS (W63/M13 & W58) & Blacks/Hispanics in SHARe & W54
                                                                                                                                                                                          BA24Metabolomics of CHD in the WHIKathryn RexrodeGeneral population
                                                                                                                                                                                          • chd (2210,0)
                                                                                                                                                                                          • Controls (2210)
                                                                                                                                                                                          BA25Leukocyte telomere dynamics, cardiovascular aging and survival in the WHI Long Life Study in the WHI Long Life StudyAlexander ReinerGeneral population
                                                                                                                                                                                            M1Diet and lifestyle factors reducing risk for age-related eye disease (AS105 extension)Julie MaresOS
                                                                                                                                                                                              M3NCI Cancer Genetic Markers of Susceptibility (CGEMS) Initiative: Replication Phase​Stephen Chanock​​OS
                                                                                                                                                                                              • breast C. (2956,0)
                                                                                                                                                                                              • Controls (2956)
                                                                                                                                                                                              Caucasians only.
                                                                                                                                                                                              M4​Whole genome scan for pancreatic cancer risk in the pancreatic cancer cohort consortium (PANSCAN)Rachael Stolzenberg-Solomon​General population
                                                                                                                                                                                              • pancreatic C. (283,0)
                                                                                                                                                                                              • Controls (283)
                                                                                                                                                                                              M5SHARe (SNP Health Association Resource) GWAS​​General population
                                                                                                                                                                                              • Controls (12007)
                                                                                                                                                                                              Blacks, Hispanics who signed Supplemental Consent
                                                                                                                                                                                              M6Population Architecture using Genomics and Epidemiology (PAGE)​Charles Kooperberg​​General population
                                                                                                                                                                                              • breast C. - invasive (1961,0)
                                                                                                                                                                                              • ovarian C. (703,0)
                                                                                                                                                                                              • stroke (3455,0)
                                                                                                                                                                                              • lymphoma, non hodgkins (843,0)
                                                                                                                                                                                              • endometrial C. (1103,0)
                                                                                                                                                                                              • melanoma - skin (1102,0)
                                                                                                                                                                                              • C. of lung (1751,0)
                                                                                                                                                                                              • chd (4274,0)
                                                                                                                                                                                              • type 2 diabetes (4000,0)
                                                                                                                                                                                              • colorectal C. (1436,0)
                                                                                                                                                                                              • Controls (16000)
                                                                                                                                                                                              ~20,000 ppts (cases & controls) every year for 4 years (new set of outcomes each year)
                                                                                                                                                                                              M8​NCI GWAS in bladder cancerStephen Chanock​​General population
                                                                                                                                                                                              • C. of bladder (420,0)
                                                                                                                                                                                              • Controls (420)
                                                                                                                                                                                              All non-Hispanic Caucasians; 28 non-dbGaP cases only for Taqman
                                                                                                                                                                                              M9​NCI GWAS in renal cell carcinoma (RCC): expansion of a primary scanMark Purdue​General population
                                                                                                                                                                                              • C. of kidney (299,0)
                                                                                                                                                                                              • Controls (298)
                                                                                                                                                                                              Non-Hispanic caucasians; 20 dbGaP ineligible ppts for Taqman only.​
                                                                                                                                                                                              M11NCI - Upper GI cancer GWAS and telomere length evaluation (includes M10)Phil TaylorGeneral population
                                                                                                                                                                                              • C. of stomach (145,0)
                                                                                                                                                                                              • C. of esophagus (28,38)
                                                                                                                                                                                              • Controls (346)
                                                                                                                                                                                              Esophagus cancer have only GWAS
                                                                                                                                                                                              M12Use of urinary sugars biomarker to assess measurement error structure of self-reported intake in NPAASVictor KipnisDM
                                                                                                                                                                                              • Controls (450)
                                                                                                                                                                                              450 NPAAS ppts
                                                                                                                                                                                              M13Genome-wide Association Studies of Treatment Response in Randomized Clinical TrialsAlexander ReinerHT/OS
                                                                                                                                                                                              • stroke (351,351)
                                                                                                                                                                                              • chd (520,520)
                                                                                                                                                                                              • vte (313,313)
                                                                                                                                                                                              • type 2 diabetes (1080,0)
                                                                                                                                                                                              • Controls (2805)
                                                                                                                                                                                              Controls #s include 174 case/control pairs with multiple outcomes, 200 SHARe ppts
                                                                                                                                                                                              M16International Stroke Genetics ConsortiumSylvia Wassertheil-SmollerOS
                                                                                                                                                                                              • stroke (844,0)
                                                                                                                                                                                              dbGaP eligible cases from AS126
                                                                                                                                                                                              M18Breast cancer post GWASDavid HunterGeneral population
                                                                                                                                                                                              • breast C. (5766,0)
                                                                                                                                                                                              • Controls (5437)
                                                                                                                                                                                              Caucasians from W21, BA2, and M6
                                                                                                                                                                                              M24WHI Sequencing Project (WHISP)Rebecca JacksonGeneral population
                                                                                                                                                                                              • type 2 diabetes (165,0)
                                                                                                                                                                                              • mi (161,161)
                                                                                                                                                                                              • stroke (770,340)
                                                                                                                                                                                              • Controls (1865)
                                                                                                                                                                                              Phase I: BMI/T2D, early MI.  Phase II: Stroke, Hypertension, Deeply Phenotyped Reference Group (DPR); Phase III: extra BMI and Stroke; Replication: 8950 samples (stroke+controls 3000; EOMI+Controls 5000; BP hi/lo 950 )
                                                                                                                                                                                              M25GWAS of chronic periodontitisJean Wactawski-WendeOS
                                                                                                                                                                                                M26The colorectal cancer sequencing project (Phase II/III)/Whole Exome Sequencing for Colorectal Cancer (Phase I)Ulrike PetersGeneral population
                                                                                                                                                                                                • colorectal C. (3000,0)
                                                                                                                                                                                                • Controls (2600)
                                                                                                                                                                                                Caucasians only
                                                                                                                                                                                                ​W1Core Analytes in a 6% Subsample​
                                                                                                                                                                                                W2OS-measurement precision study (OS-MPS)​OS
                                                                                                                                                                                                • Controls (800)
                                                                                                                                                                                                B, 3 month​
                                                                                                                                                                                                W3​Misc Core pulls​​General population
                                                                                                                                                                                                Place holder for QA pulls for labeling blind dups, cholesterol pulls to PPD for aliquoting QC
                                                                                                                                                                                                W4​National validation and quality control assurance of vitamin D absorption from CaD tablets for WHI​CaD
                                                                                                                                                                                                • Controls (448)
                                                                                                                                                                                                W5​Correlates of endogenous sex hormone concentrations in DM trial​DM
                                                                                                                                                                                                • Controls (300)
                                                                                                                                                                                                150 DM Intervention + 150 DM controls at B and Y1
                                                                                                                                                                                                W6​HT CVD Biomarkers: study of CHD, Stroke and VTE - Phase I​HT
                                                                                                                                                                                                • stroke (272,272)
                                                                                                                                                                                                • chd (402,402)
                                                                                                                                                                                                • vte (223,223)
                                                                                                                                                                                                • Controls (877)
                                                                                                                                                                                                B, Y1
                                                                                                                                                                                                W7​Genome-wide scan on breast cancer, CHD, and strokeGeneral population
                                                                                                                                                                                                • chd (2119,2219)
                                                                                                                                                                                                • stroke (2215,2013)
                                                                                                                                                                                                • breast C. (2145,2245)
                                                                                                                                                                                                • Controls (6479)
                                                                                                                                                                                                W8Nutritional biomarkers study (NBS)​​General population
                                                                                                                                                                                                • chd (2119,2219)
                                                                                                                                                                                                • stroke (2215,2013)
                                                                                                                                                                                                • breast C. (2145,2245)
                                                                                                                                                                                                • Controls (6479)
                                                                                                                                                                                                W9Biological markers of the effect of HT on risk of fractures in the Women's Health Initiative clinical trial​HT
                                                                                                                                                                                                • fracture - hip (750,0)
                                                                                                                                                                                                • Controls (750)
                                                                                                                                                                                                Cases=248 hip fractures + 502 non-spine fractures​
                                                                                                                                                                                                W10Biological markers of the effect of HT on risk of breast cancer in the Women's Health Initiative clinical trial HT
                                                                                                                                                                                                • breast C. (755,0)
                                                                                                                                                                                                • Controls (755)
                                                                                                                                                                                                498 E+P and 260 E-Alone cases through Sept 2005; B+Y1
                                                                                                                                                                                                W11CVD biomarkers - Phase II:  strokes after Feb. 2001 HT
                                                                                                                                                                                                • stroke (326,0)
                                                                                                                                                                                                • Controls (326)
                                                                                                                                                                                                108 new E+P cases up to July 2002, 174 E alone cases up to March 2004; B+Y1
                                                                                                                                                                                                W14CVD biomarkers - Phase I: additional asays HT
                                                                                                                                                                                                • chd (390,402)
                                                                                                                                                                                                • stroke (270,272)
                                                                                                                                                                                                • vte (220,223)
                                                                                                                                                                                                • Controls (880)
                                                                                                                                                                                                B, Y1
                                                                                                                                                                                                W15Vitamin D levels in CaD participants with colorectal cancer or fractures CaD
                                                                                                                                                                                                • fracture - elbow, lower humerous (853,0)
                                                                                                                                                                                                • fracture - hip (360,0)
                                                                                                                                                                                                • colorectal C. (334,0)
                                                                                                                                                                                                • fracture - spine only (283,0)
                                                                                                                                                                                                • Controls (1830)
                                                                                                                                                                                                Y1; B only if Y1 not available
                                                                                                                                                                                                W18HT Hormone Pretest HT
                                                                                                                                                                                                • Controls (240)
                                                                                                                                                                                                120 active + 120 placebo; B, Y1
                                                                                                                                                                                                W19WHI HT Proteomic Pilot Study HT
                                                                                                                                                                                                • Controls (200)
                                                                                                                                                                                                100 active, 100 control; B, AV1
                                                                                                                                                                                                W20WHI-EDRN pilot study for the identification of circulating biomarkers for colon cancer in pre-clinical specimens OS
                                                                                                                                                                                                • colorectal C. (100,0)
                                                                                                                                                                                                • Controls (120)
                                                                                                                                                                                                Colon cancer cases 6-18 mo after Year 3
                                                                                                                                                                                                W21NCI Cancer Genetic Markers of Susceptibility (See study ref # M3) OS
                                                                                                                                                                                                • breast C. (,0)
                                                                                                                                                                                                Caucasians only.
                                                                                                                                                                                                W22Vitamin D levels in 6% blood subsample of CaD CaD
                                                                                                                                                                                                • Controls (600)
                                                                                                                                                                                                CaD at AV1 and AV3, about 200 AA, 100 Hispanics, and 300 Caucasians
                                                                                                                                                                                                W24Vitamin D and breast cancer in CaD trial CaD
                                                                                                                                                                                                • breast C. (1081,0)
                                                                                                                                                                                                • Controls (1081)
                                                                                                                                                                                                Use controls from W15 when possible
                                                                                                                                                                                                W25WHI coronary artery calcification study in E-alone (WHI-CACS)JoAnn MansonHT
                                                                                                                                                                                                  1150 E-Alone ppts aged 50-59
                                                                                                                                                                                                  W27Nutrition and physical activity assessment study (AS218) lab work OS
                                                                                                                                                                                                    450 ppts
                                                                                                                                                                                                    W29NCI Pancreatic Cancer Cohort Consortium (See study ref #M4) General population
                                                                                                                                                                                                    • pancreatic C. (,0)
                                                                                                                                                                                                    W30Dietary assessment study DM
                                                                                                                                                                                                      160  ppts for 4DFR analyses, repeat 24 hr recalls, and repeat FFQs
                                                                                                                                                                                                      W314DFR on DM ovarian cancers DM
                                                                                                                                                                                                      • ovarian C. (160,0)
                                                                                                                                                                                                      For DM Other Cancer paper
                                                                                                                                                                                                      W334DFR and DM breast cancer DM
                                                                                                                                                                                                      • breast C. (1800,0)
                                                                                                                                                                                                      For DM Breast Cancer paper
                                                                                                                                                                                                      W34Extension of WHI stroke genome-wide association study (W-7) General population
                                                                                                                                                                                                      • stroke (2096,0)
                                                                                                                                                                                                      • Controls (2096)
                                                                                                                                                                                                      W3927-hydroxycholesterol in CVD biomarkers (W-6) HT
                                                                                                                                                                                                      • chd (359,0)
                                                                                                                                                                                                      • Controls (820)
                                                                                                                                                                                                      CHD cases from W6-HT CVD Biomarkers
                                                                                                                                                                                                      W40Validation of E-alone proteins in W19-HT proteomics HT
                                                                                                                                                                                                      • Controls (100)
                                                                                                                                                                                                      100 E-Alone ppts in active treatment arm
                                                                                                                                                                                                      W43Gene sequencing of selected genes in breast cancer and stroke SNP studies (W7 and W34) HT E+P
                                                                                                                                                                                                      • breast C. (60,0)
                                                                                                                                                                                                      • Controls (60)
                                                                                                                                                                                                      60 active treatment. 60 placebo
                                                                                                                                                                                                      W44Biological validation of E+P effects on the serum proteome and comparison of E+P and E-Alone effects (see W19 and W40) HT
                                                                                                                                                                                                      • Controls (50)
                                                                                                                                                                                                      50 E+P ppts at baseline,AV1
                                                                                                                                                                                                      W45Proteomic Colon Cancer StudySam HanashOS
                                                                                                                                                                                                      • colon C. (100,0)
                                                                                                                                                                                                      • Controls (100)
                                                                                                                                                                                                      ​W47Breast Tissue Pilot Study​​Garnet Anderson​504 DM ppts w/ invasive BC diagnosis
                                                                                                                                                                                                      W54CVD Biomarkers for 2010-2015 (SHARe cohort only) General population
                                                                                                                                                                                                      • Controls (12008)
                                                                                                                                                                                                      SHARe ppts (12,008)
                                                                                                                                                                                                      W57Proposal to Extend CVD Biomarker Study using HT Proteomics Study Findings on B2M and IGFBP2,4 General population
                                                                                                                                                                                                      • stroke (341,341)
                                                                                                                                                                                                      • chd (354,354)
                                                                                                                                                                                                      • Controls (695)
                                                                                                                                                                                                      W58CVD, diabetes, and renal biomarkers in the EA HT Cohort HT
                                                                                                                                                                                                      • Controls (10254)
                                                                                                                                                                                                      AS39-WHIMS (6061) + M13-GARNET (3015) + subset of HT EA aged 65 and over (279) and under 65 (899)
                                                                                                                                                                                                      W59Collaborative telomere studies pilot study Jacques RossouwHT
                                                                                                                                                                                                      • Controls (60)
                                                                                                                                                                                                      W63GWAS on WHIMS and subsample of HT EA women HT
                                                                                                                                                                                                      • Controls (5907)
                                                                                                                                                                                                      Non-GARNET WHIMS (4661) + HT EA ppts aged 65+ (300) and under 65 (946)
                                                                                                                                                                                                      W64Long Life StudyAndrea LaCroixGeneral population
                                                                                                                                                                                                        8,000 MRC ppts with GWAS and Baseline Biomarkers
                                                                                                                                                                                                        W66Long Life Study-Phase III Biomarkers and GWAS General population
                                                                                                                                                                                                        • Controls (1500)
                                                                                                                                                                                                        Ppts are the 1500 Phase III women in the Long Life Study. Unlike women in LLS Phases I &2, these women were not included in W54 or W58 and also not included in M5, M13, or W64.