Investigator Names and Contact Information
Charles Kooperberg, PhD, FHCRC [email@example.com ]
Specific Aim #1: To examine the population-based profile of putative genuine variants for a variety of complex diseases and traits, such as cardiovascular diseases (adjudicated myocardial infarction, stroke and cardiovascular death), diabetes, cancer (breast, lung, colorectal), fractures, obesity, and dementia, and to investigate differences by disease subtypes and characteristics.
Specific Aim #2: To evaluate potential modifiers of genetic variant-disease associations, including environmental and life style factors, medication use, as well as three randomized interventions (hormone replacement therapy; low-fat dietary modification; calcium and vitamin D supplementation).
Specific Aim #3: To investigate associations between genuine variants and relevant intermediate outcomes and phenotypic characteristics, such as bone density and body composition, electrocardiogram abnormalities, blood pressure, breast density, leukocyte count, or blood concentrations of lipids, inflammatory markers, insulin, glucose, and hormones.