Introduction/IntentNHLBI provided funds to genotype the African American and Hispanic sub-cohort of the WHI as part of the NHLBI SNP Health Association Resource (SHARe). SHARe was initiated in 2007 to create a widely shared resource of genome-wide SNP typing and multiple phenotypes for gene discovery and replication (also known as Genome-Wide Association Studies or GWAS). See this site for more information: https://www.nhlbi.nih.gov/resources/geneticsgenomics/programs/share.htm.
Study Name (ID)
Study population (synopsis)
AA & H GWAS**
Selected dbGaP-eligible African American (AA) and Hispanic (H) in the OS & CT.
(Not all dbGaP-eligible AA & H ppts were tested due to budget constraints.)
(AA: N~8,405, Hispanic: N~3,602)
See also http://www.nhlbi.nih.gov/whi/ .
GWAS - Affymetrix 6.0
GWAS and phenotype data available on dbGaP: http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000200.v9.p3
WHI phenotype data to be updated on dbGaP annually.
Baseline clinical biomarker data (glucose, insulin, creatinine, CRP, triglycerides, cholesterol, HDL, and LDL) are available for all EA, AA, and Hispanic participants in SHARe (with sample available).