Investigator Names and Contact Information
Stephen Chanock, MD, NCI
To help meet the Challenge Goal of eliminating suffering and death from cancer by 2015, the NCI is capitalizing on the extraordinary momentum generated by advances in human genetic research. The sequencing of the human genome and the annotation of common variations, together with new technologies for analyzing SNPs, have provided the tools for investigators to actively search for inherited variants in genes that increase or decrease cancer risk. The convergence of sequencing the human genome, rapid progress in the International HapMap project, and the development of technologies that permit very large-scale SNP genotyping has made it possible to execute well-designed association studies using common variants across the entire genome to map low-penetrant genes involved in cancer susceptibility. The results of such studies are expected to open new vistas in the search for causal pathways in cancer induction and progression that will lead to targets for novel intervention strategies.