David Hunter [email@example.com]
This post-GWA project "Discovery, Biology and Risk of Inherited Variants in Breast Cancer" is designed to systematically discover and fine map new genetic loci that influence breast cancer risk, explore their biological impact, and to begin to translate these findings into clinically useful tools to assess the risk associated with inheritance of multiple alleles and their potential interaction with each other and with established non-genetic risk factors. To do this we have assembled a multi-disciplinary team that includes the largest pre-existing Consortia researching the genetics of breast cancer, and computational biologists and basic scientists with a strong track record in the investigation of mechanisms by which genetic loci may influence breast cancer risk.
Overall Goals of the RFA:
Goal 1. To pursue promising scientific leads from initial Genome Wide Association Studies (GWAS) of cancer (exploiting previously generated "initial scan" GWAS data).
Goal 2. To accelerate and coordinate integrative post-GWAS discovery research, which could provide the basis for expediting clinical translation and public health dissemination of the findings.
Modification 1: Use leftover DNA samples for Oncochip at CIDR
Specific Aims for Mod 1: