This page provides study documentation for BA22. For description of the specimen results, see Specimen Results Description (open to public). Data sets of the specimen results are included in the existing WHI datasets located on the WHI Data on this site (sign in and a completed Data Distribution Agreement are required; see details on the Data site).
Investigator Names and Contact Information
Risk prediction models for cardiovascular disease have been developed primarily among white men and women, with little validation in multi-ethnic populations. The Women’s Health Initiative (WHI) Observational Study (OS) provides an excellent opportunity to examine the fit of current models as well as to determine whether these can be improved, particularly within under-represented subpopulations. The overall aim of the current proposal is to validate existing, and explore new, predictive models for 10-year risk of cardiovascular disease (CVD), including MI, stroke, and CVD mortality in this multiethnic population-based cohort of women. An efficient case-cohort sample of 4000 women will be used, including 2000 cases, with over-sampling of under-represented minority racial/ethnic groups, and a subcohort of approximately 2000 women frequency matched to the cases by race/ethnicity and 10-year age groups. A strength of the nested case-cohort design is the ability to use the same subcohort sample as a reference for more than one outcome. As such, we will fit models for total cardiovascular disease (CVD), including coronary heart disease (CHD) (myocardial infarction [MI] and CHD death), stroke, and CVD mortality, as well as models for CHD and stroke separately.
See Publications: 1272, 1496, 1745. WHI publications by study lists published WHI papers that have been generated by ancillary studies. A complete list of WHI papers is available in the Bibliography section of this website.