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Investigator Names and Contact Information
Ross Prentice [firstname.lastname@example.org]
This research has two aims, each of which includes coronary heart disease and stroke sub-aims. Prior studies based on in-depth quantitative proteomic mass spectrometry profiling of plasma samples collected before a diagnosis of CHD or stroke among subjects in the Women's Health Initiative study cohort, compared with matched controls from the same cohort, have identified a subset of proteins in plasma as novel candidate risk markers. Additionally proteomic profiling of blood specimens collected before and after hormone replacement therapy led to findings of a substantial effect of HRT on the plasma proteome, including some of the protein candidates we have identified as associated with risk for CHD and stroke. These provocative findings require further validation in an independent set of cases and controls, which we propose to undertake using ELISA based assays.