This page provides study documentation for AS296. For description of the specimen results, see Specimen Results Description (open to public). Data sets of the specimen results are included in the existing WHI datasets located on the WHI Data on this site (sign in and a completed Data Distribution Agreement are required; see details on the Data site).
Investigator Names and Contact Information
Katherine McGlynn, Ph.D., MPH [firstname.lastname@example.org]
Prior studies of HCC in the U.S. have been hampered by the rarity of the tumor. In addition, most previous studies have employed a retrospective design, raising questions about the influence of recall bias. The identification of risk factors through prospective analyses is needed, although it is difficult to assemble sufficient numbers of cases in any individual study. A consortial approach has therefore been adopted, in which data from a number of studies will be pooled to derive sufficient power. Cohorts with serum samples will be especially valuable in order to a analyses for the known HCC risk factors: HBV and HCV infection. Questionnaire data and serum samples are being sought from all U.S. studies in the NCI Cohort Consortium for this effort.