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Investigator Names and Contact Information
Mattias Johansson, Ph.D. [JohanssonM@iarc.fr]
We recently conducted a study of circulating B-vitamins and lung cancer within the EPIC cohort based on 900 cases and 1,800 controls. The study strongly implicated important protective effects of vitamin B6 and methionine independent of tobacco smoking. Combined analysis resulted in an approximate 3-fold risk difference between the top and bottom 25% of the population for concentrations of vitamin B6 and methionine.
The overall aim of this expanded study is to elucidate the role of one-carbon metabolism in lung cancer etiology in a study population large enough to allow stratified robust analyses by smoking status, histology and socio-economic status. We will assess risk profiles for groups stratified on B-vitamin levels and smoking status, and correct risk estimates for regression dilution. In addition we will investigate if these associations for B-vitamins also translate to Asian populations with important differences in dietary and genetic background.