[This site contains pages, such as this, to describe your study. In addition, pre-created "Document Libraries" (much like file folders on a PC) are set up for the storage of raw and analytical datasets, data dictionaries, data preparation documents, and other relevant study documentation. For help in using the features of this site, along with guidelines for data submission, please consult the Data Submission Guidelines and Help Topics]
Investigator Names and Contact Information
Polly Newcomb, Ph.D. [email@example.com]
Most of the established risk factors for breast cancer are believed to act through changes in endogenous or exogenous hormone levels. Cadmium is a widespread heavy metal environmental pollutant resulting from industrial and agricultural practices, which accumulates in the body over a lifetime. In vitro experiments show that cadmium may have estrogenic properties. Therefore, we hypothesize that cadmium body burden is a risk factor for breast cancer. We have previously found an association between high cadmium body burden, assessed by measurement of urinary cadmium, and risk of breast cancer in a pilot, cross-sectional case-control study. We now plan to test further test our hypothesis within the Women’s Health Initiative (WHI) study. The ~11,000 participants in the WHI Bone Density sub-study donated urine prospectively at enrollment in the study. We plan to conduct a case-cohort study to assay these urine samples for cadmium burden, and combined with questionnaire data, examine the association between urinary cadmium level and incidence of breast cancer.