[This page is intended to provide a study summary, the sections of which are below. Please complete these sections, as applicable. The headings below are suggested headings. You can remove inapplicable sections, or add new ones relevant to your study]
Investigator Names and Contact Information
Gloria Ho, Ph.D. [firstname.lastname@example.org]
Although smoking is the major cause of lung cancer, there remains many gaps in our knowledge of its etiology, which is thought to be heterogeneous by smoking status, gender, and histological subtype. The purpose of this study is to elucidate the risk factors of lung cancer in these individual subgroups. We will focus on the serum levels of 6 physiological factors that activate (IGF-I, HGF, NGF, insulin, and IL-6) or inhibit (IGFBP-3) the epidermal growth factor receptor (EGFR) signaling network, which encompasses multiple pathways regulating cell proliferation, survival, and migration. It will be a nested case-control study with 973 lung cancer cases and 1,126 controls in the WHI Observational Study cohort. We will examine if serum/plasma levels of the 6 activators/inhibitor are associated with risk of lung cancer, and whether the associations vary depending on smoking status and histological subtype. The large WHI cohort provides a rare opportunity to study the heterogeneous etiology of lung cancers in subgroups of women. Identifying susceptibility factors in smokers and risk factors in never-smokers will provide insights into the development of lung cancer screening and prevention programs for women.