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Investigator Names and Contact Information
Joel Kaufman, MD, MPH
Assess the effect of long-term exposure to fine
particulate matter air pollution and other pollutants on the incidence of
cardiovascular events in the Women’s Health Initiative Observational Study,
adjusting for potential confounders and assessing effect modifiers. Assessment of effect modification by subject
characteristics may provide insight into susceptibility to, or mechanisms of,
PM health effects.
1) To determine the association between long-term exposures to fine particulate air pollution and incident cardiovascular events and total mortality in 50-79 year-old women, using proportional hazards modeling. The effects of other pollutants will also be considered.
2) To determine the degree to which subject characteristics (including sedentary lifestyle and prior health conditions) modify the relationship between air pollution and cardiovascular events.